An unexpected role for decorin in delayed type hypersensitivity
Abdullah Emtawel Mohamed:An unexpected
Autor: | Negia Abdullah Emtawel Mohamed |
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Verfügbarkeit: | Auf Lager. |
Artikelnummer: | 1809847 |
ISBN / EAN: | 9783330026810 |
Produktbeschreibung
Decorin is a member of small leucine-rich repeat proteoglycans. It is ubiquitously expressed, primarily in the skin. It participates in extracellular matrix assembly. It plays a role in cell adhesion and migration processes directly and indirectly via interactions with membrane receptors. Delayed-type hypersensitivity (DTH) response in mice is widely used as a model of allergic contact dermatitis, allowing the study of cell-mediated immune response in vivo. We demonstrated that decorin modulates oxazolone-induced DTH reactions in mice. These findings were associated with an increased percentage of circulating decorin-deficient neutrophils.Decorin-deficient polymorphonuclear cells (PMNs) display an increased adhesion to endothelial cells in vitro compared to the wild-type. This is consistent with increase adhesion of Decorin-deficient leukocytes to the blood vessel wall in our DTH model in vivo. Collectively, absence of decorin exerts a protective effect on oxazolone-induced contact hypersensitivity reactions. This may lead to the development of new strategies in the treatment of contact dermatitis
Zusatzinformation
Autor | Negia Abdullah Emtawel Mohamed | Verlag | LAP Lambert Academic Publishing |
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ISBN / EAN | 9783330026810 | Bindung | Taschenbuch |
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